Multi-omics analyses of the ulcerative colitis gut microbiome link Bacteroides vulgatus proteases with disease severity.
Nat Microbiol. 2022 Jan 27 [online ahead of print]
Mills RH, Dulai PS, Vázquez-Baeza Y, Sauceda C, Daniel N, Gerner RR, Batachari LE, Malfavon M, Zhu Q, Weldon K, Humphrey G, Carrillo-Terrazas M, Goldasich LD, Bryant M, Raffatellu M, Quinn RA, Gewirtz AT, Chassaing B, Chu H, Sandborn WJ, Dorrestein PC, Knight R, Gonzalez DJ
Native mass spectrometry-based metabolomics identifies metal-binding compounds.
Nat Chem. 2022 Jan;14(1):100-109
Aron AT, Petras D, Schmid R, Gauglitz JM, Büttel I, Antelo L, Zhi H, Nuccio SP, Saak CC, Malarney KP, Thines E, Dutton RJ, Aluwihare LI, Raffatellu M, Dorrestein PC
Siderophore-mediated zinc acquisition enhances enterobacterial colonization of the inflamed gut.
Nat Commun. 2021 Dec 1;12(1):7016
Behnsen J, Zhi H, Aron AT, Subramanian V, Santus W, Lee MH, Gerner RR, Petras D, Liu JZ, Green KD, Price SL, Camacho J, Hillman H, Tjokrosurjo J, Montaldo NP, Hoover EM, Treacy-Abarca S, Gilston BA, Skaar EP, Chazin WJ, Garneau-Tsodikova S, Lawrenz MB, Perry RD, Nuccio SP, Dorrestein PC, Raffatellu M
- Editors’ Highlights, Microbiology and Infectious Diseases, Nature Communications, FOCUS, 26 JANUARY 2021. | Links: DirectLink
Ion identity molecular networking for mass spectrometry-based metabolomics in the GNPS environment.
Nat Commun. 2021 Jun 22;12(1):3832
Schmid R, Petras D, Nothias LF, Wang M, Aron AT, Jagels A, Tsugawa H, Rainer J, Garcia-Aloy M, Dührkop K, Korf A, Pluskal T, Kameník Z, Jarmusch AK, Caraballo-Rodríguez AM, Weldon KC, Nothias-Esposito M, Aksenov AA, Bauermeister A, Albarracin Orio A, Grundmann CO, Vargas F, Koester I, Gauglitz JM, Gentry EC, Hövelmann Y, Kalinina SA, Pendergraft MA, Panitchpakdi M, Tehan R, Le Gouellec A, Aleti G, Mannochio Russo H, Arndt B, Hübner F, Hayen H, Zhi H, Raffatellu M, Prather KA, Aluwihare LI, Böcker S, McPhail KL, Humpf HU, Karst U, Dorrestein PC
Conjugation to Enterobactin and Salmochelin S4 Enhances the Antimicrobial Activity and Selectivity of β-Lactam Antibiotics against Nontyphoidal Salmonella.
ACS Infect Dis. 2021 May 14;7(5):1248-1259
Sargun A, Sassone-Corsi M, Zheng T, Raffatellu M, Nolan EM
Enterobactin- and salmochelin-β-lactam conjugates induce cell morphologies consistent with inhibition of penicillin-binding proteins in uropathogenic Escherichia coli CFT073.
Chem. Sci. 2021 Feb;12:4041-4056
Sargun A, Johnstone TC, Zhi H, Raffatellu M, Nolan EM
The interaction of enteric bacterial effectors with the host engulfment pathway control innate immune responses.
Gut Microbes. 2021 Jan-Dec;13(1):1991776
Sayed IM, Ibeawuchi SR, Lie D, Anandachar MS, Pranadinata R, Raffatellu M, Das S
CCL28 modulates neutrophil responses and impacts the trajectory of mucosal infections.
bioRxiv.
Perez-Lopez A, Silva S, Dillon N, Brandt SL, Gerner RR, Lee MH, Melchior K, Torres-Ruiz J, Sosa-Hernandez VA, Cervantes-Diaz R, Perez-Fragoso A, Romero-Ramirez S, Gomez-Martin D, Maravillas-Montero JL, Nuccio SP, Nizet V, Raffatellu M
CD8 T cells drive anorexia, dysbiosis, and blooms of a commensal with immunosuppressive potential after viral infection.
Proc Natl Acad Sci U S A. 2020 Oct 6;117(40):24998-25007.
Labarta-Bajo L, Gramalla-Schmitz A, Gerner RR, Kazane KR, Humphrey G, Schwartz T, Sanders K, Swafford A, Knight R, Raffatellu M, Zúñiga EI
Targeted Depletion of Bacteria from Mixed Populations by Programmable Adhesion with Antagonistic Competitor Cells
Cell Host Microbe. 2020 May 22:S1931-3128(20)30288-2.
Ting SY, Martínez-García E, Huang S, Bertolli SK, Kelly KA, Cutler KJ, Su ED, Zhi H, Tang Q, Radey MC, Raffatellu M, Peterson SB, de Lorenzo V, Mougous JD
Global chemical effects of the microbiome include new bile-acid conjugations
Nature. 2020 Mar;579(7797):123-129.
Quinn RA, Melnik AV, Vrbanac A, Fu T, Patras KA, Christy MP, Bodai Z, Belda-Ferre P, Tripathi A, Chung LK, Downes M, Welch RD, Quinn M, Humphrey G, Panitchpakdi M, Weldon KC, Aksenov A, da Silva R, Avila-Pacheco J, Clish C, Bae S, Mallick H, Franzosa EA, Lloyd-Price J, Bussell R, Thron T, Nelson AT, Wang M, Leszczynski E, Vargas F, Gauglitz JM, Meehan MJ, Gentry E, Arthur TD, Komor AC, Poulsen O, Boland BS, Chang JT, Sandborn WJ, Lim M, Garg N, Lumeng JC, Xavier RJ, Kazmierczak BI, Jain R, Egan M, Rhee KE, Ferguson D, Raffatellu M, Vlamakis H, Haddad GG, Siegel D, Huttenhower C, Mazmanian SK, Evans RM, Nizet V, Knight R, Dorrestein PC.
CRTAM Shapes the Gut Microbiota and Enhances the Severity of Infection
J Immunol. 2019 Jul 15;203(2):532-543.
Perez-Lopez A, Nuccio SP, Ushach I, Edwards RA, Pahu R, Silva S, Zlotnik A, Raffatellu M
CCL28 Is Involved in Mucosal IgA Responses, Olfaction, and Resistance to Enteric Infections
J Interferon Cytokine Res. 2019 Apr;39(4):214-223.
Burkhardt AM, Perez-Lopez A, Ushach I, Catalan-Dibene J, Nuccio SP, Chung LK, Hernandez-Ruiz M, Carnevale C, Raffatellu M, Zlotnik A
Genome-scale metabolic reconstructions of multiple Salmonella strains reveal serovar-specific metabolic traits
Nat Commun. 2018 Sep 14;9(1):3771.
Seif Y, Kavvas E, Lachance JC, Yurkovich JT, Nuccio SP, Fang X, Catoiu E, Raffatellu M, Palsson BO, Monk JM
Defining Host Responses during Systemic Bacterial Infection through Construction of a Murine Organ Proteome Atlas
Cell Syst. 2018 May 23;6(5):579-592.e4.
Lapek JD Jr, Mills RH, Wozniak JM, Campeau A, Fang RH, Wei X, van de Groep K, Perez-Lopez A, van Sorge NM, Raffatellu M, Knight R, Zhang L, Gonzalez DJ
Esterase-Catalyzed Siderophore Hydrolysis Activates an Enterobactin-Ciprofloxacin Conjugate and Confers Targeted Antibacterial Activity
J Am Chem Soc. 2018 Apr 18;140(15):5193-5201.
Neumann W, Sassone-Corsi M, Raffatellu M, Nolan EM
Mechanisms to Evade the Phagocyte Respiratory Burst Arose by Convergent Evolution in Typhoidal Salmonella Serovars
Cell Rep. 2018 Feb 13;22(7):1787-1797.
Hiyoshi H, Wangdi T, Lock G, Saechao C, Raffatellu M, Cobb BA, Bäumler AJ
Identification of IL-40, a Novel B Cell-Associated Cytokine
J Immunol. 2017 Nov 1;199(9):3326-3335.
Catalan-Dibene J, Vazquez MI, Luu VP, Nuccio SP, Karimzadeh A, Kastenschmidt JM, Villalta SA, Ushach I, Pone EJ, Casali P, Raffatellu M, Burkhardt AM, Hernandez-Ruiz M, Heller G, Hevezi PA, Zlotnik A
Bariatric surgery attenuates colitis in an obese murine model
Surg Obes Relat Dis. 2016 Dec 20. pii: S1550-7289(16)30797-3.
Li S, Vinci A, Behnsen J, Cheng C, Jellbauer S, Raffatellu M, Sousa KM, Edwards R, Nguyen NT, Stamos MJ, Pigazzi A
Siderophore-based immunization strategy to inhibit growth of enteric pathogens
Proc Natl Acad Sci U S A. 2016 Nov 22;113(47):13462-7.
Sassone-Corsi M, Chairatana P, Zheng T, Perez-Lopez A, Edwards RA, George MD, Nolan EM, Raffatellu M
- Spotlight by Corrie Detweiler: “A New Way to Beat Intestinal Pathogens”, Trends Microbiol. 2017 Mar;25(3):169-170. | Links: PubMed, DirectLink
Microcins mediate competition among Enterobacteriaceae in the inflamed gut
Nature. 2016 Dec 8;540(7632):280-283.
Sassone-Corsi M, Nuccio SP, Liu H, Hernandez D, Vu CT, Takahashi AA, Edwards RA, Raffatellu M
- Research Highlight by Sarah Crunkhorn: “Microcins limit intestinal infection”, Nature Reviews Drug Discovery. 2017; 16:18. | Links: PubMed, DirectLink
Beneficial Effects of Sodium Phenylbutyrate Administration During Infection with Salmonella enterica serovar Typhimurium
Infect Immun. 2016 Aug 19;84(9):2639-52.
Jellbauer S, Perez Lopez A, Behnsen J, Gao N, Nguyen T, Murphy C, Edwards RA, Raffatellu M
Salmonella Mitigates Oxidative Stress and Thrives in the Inflamed Gut by Evading Calprotectin-Mediated Manganese Sequestration
Cell Host Microbe. 2016 Jun 8;19(6):814-25.
Diaz-Ochoa VE, Lam D, Lee CS, Klaus S, Behnsen J, Liu JZ, Chim N, Nuccio SP, Rathi SG, Mastroianni JR, Edwards RA, Jacobo CM, Cerasi M, Battistoni A, Ouellette AJ, Goulding CW, Chazin WJ, Skaar EP, Raffatellu M
- Cover article
Gut immune dysfunction through impaired innate pattern recognition receptor expression and gut microbiota dysbiosis in chronic SIV infection
Mucosal Immunol. 2015 Sep 16.
Glavan TW, Gaulke CA, Santos Rocha C, Sankaran-Walters S, Hirao LA, Raffatellu M, Jiang G, Bäumler AJ, Goulart LR, Dandekar S
Salmonella infection inhibits intestinal biotin transport: cellular and molecular mechanisms
Am J Physiol Gastrointest Liver Physiol. 2015 Jul 15;309(2):G123-31.
Ghosal A, Jellbauer S, Kapadia R, Raffatellu M, Said HM
mTOR kinase inhibitors promote antibody class switching via mTORC2 inhibition
Proc Natl Acad Sci U S A. 2014 Nov 25;111(47):E5076-85.
Limon JJ, So L, Jellbauer S, Chiu H, Corado J, Sykes SM, Raffatellu M, Fruman DA
The Cytokine IL-22 Promotes Pathogen Colonization by Suppressing Related Commensal Bacteria
Immunity. 2014 Feb 20;40(2):262-73.
Behnsen J, Jellbauer S, Wong CP, Edwards RA, George MD, Ouyang W, Raffatellu M
- Featured article, with preview by Denise Monack: “The Battle in the Gut”, Immunity. 2014 Feb 20;40(2):173-5. | Links: PubMed, DirectLink
- Press Release
The ZupT transporter plays an important role in zinc homeostasis and contributes to Salmonella enterica virulence
Metallomics. 2014 Apr;6(4):845-53.
Cerasi M, Liu JZ, Ammendola S, Poe AJ, Petrarca P, Pesciaroli M, Pasquali P, Raffatellu M, Battistoni A
Probiotic bacteria reduce Salmonella Typhimurium intestinal colonization by competing for iron
Cell Host Microbe. 2013 Jul 17;14(1):26-37.
Deriu E, Liu JZ, Pezeshki M, Edwards RA, Ochoa RJ, Contreras H, Libby SJ, Fang FC, Raffatellu M
- Cover article, with preview by Guenter Weiss: “Intestinal Irony: How Probiotic Bacteria Outcompete Bad Bugs”, Cell Host Microbe. 2013 Jul 17;14(1):3. | Links: PubMed, DirectLink
- Editor’s Choice: “Good and Bad Bacteria Fight for Iron in the Gut”, Science Translational Medicine, Vol 5, August 2013
- Press Release
Attenuated Salmonella enterica serovar Typhimurium lacking the ZnuABC transporter: An efficacious orally-administered mucosal vaccine against salmonellosis in pigs
Vaccine. 2013 Aug 12;31(36):3695-701.
Gradassi M, Pesciaroli M, Martinelli N, Ruggeri J, Petrucci P, Hassan WH, Raffatellu M, Scaglione FE, Ammendola S, Battistoni A, Alborali GL, Pasquali P
Circadian clock regulates the host response to Salmonella
Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):9897-902.
Bellet MM[1], Deriu E[1], Liu JZ, Grimaldi B, Blaschitz C, Zeller M, Edwards RA, Sahar S, Dandekar S, Baldi P, George MD, Raffatellu M[2], Sassone-Corsi P[2]
[1,2]: Contributed equally
Salmonella Typhimurium lacking the ZnuABC transporter is attenuated and immunogenic in pigs
Vaccine. 2013 Jun 12;31(27):2868-73.
Pesciaroli M, Gradassi M, Martinelli N, Ruggeri J, Pistoia C, Raffatellu M, Magistrali CF, Battistoni A, Pasquali P, Alborali GL
Uremic plasma impairs barrier function and depletes the tight junction protein constituents of intestinal epithelium
Am J Nephrol. 2012;36(5):438-43.
Vaziri ND, Goshtasbi N, Yuan J, Jellbauer S, Moradi H, Raffatellu M, Kalantar-Zadeh K
Zinc sequestration by the neutrophil protein calprotectin enhances Salmonella growth in the inflamed gut
Cell Host Microbe. 2012 Mar 15;11(3):227-39.
Liu JZ, Jellbauer S, Poe AJ, Ton V, Pesciaroli M, Kehl-Fie TE, Restrepo NA, Hosking MP, Edwards RA, Battistoni A, Pasquali P, Lane TE, Chazin WJ, Vogl T, Roth J, Skaar EP, Raffatellu M
- Featured article
- Editor’s Choice: “In need of nutrients”, Science, Vol 335, March 2012
- Research Highlights: “A competitive edge for Salmonella“, Nature Reviews Microbiology, Vol 10, May 2012
- Faculty of 1000 “Must Read”, 8
- Press Release
Enteric pathology and Salmonella-induced cell death in healthy and SIV-infected rhesus macaques
Vet Pathol. 2011 Sep;48(5):933-41.
Santos RL, Almeida AP, Xavier MN, Paixão TA, Wilson RP, Dandekar S, Raffatellu M, Bäumler AJ
Linking lipid metabolism to the innate immune response in macrophages through sterol regulatory element binding protein-1a
Cell Metab. 2011 May 4;13(5):540-9.
Im SS, Yousef L, Blaschitz C, Liu JZ, Edwards RA, Young SG, Raffatellu M, Osborne TF
- Featured article
- Research Highlights: “Linking lipids and Inflammasomes”, Nature Reviews Immunology, Vol 11, June 2011
- Faculty of 1000 “Must Read”, 8
The Salmonella enterica serotype Typhi Vi capsular antigen is expressed after the bacterium enters the ileal mucosa
Infect Immun. 2010 Jan;78(1):527-35.
Tran QT, Gomez G, Khare S, Lawhon SD, Raffatellu M, Bäumler AJ, Ajithdoss D, Dhavala S, Adams LG
Salmonella enterica serovar Typhimurium-induced internalization and IL-8 expression in HeLa cells does not have a direct relationship with intracellular Ca(2+) levels
Microbes Infect. 2009 Sep;11(10-11):850-8.
Figueiredo JF, Barhoumi R, Raffatellu M, Lawhon SD, Rousseau B, Burghardt RC, Tsolis RM, Bäumler AJ, Adams LG
Lipocalin-2 resistance confers an advantage to Salmonella enterica serotype Typhimurium for growth and survival in the inflamed intestine
Cell Host Microbe. 2009 May 8;5(5):476-86.
Raffatellu M, George MD, Akiyama Y, Hornsby MJ, Nuccio SP, Paixao TA, Butler BP, Chu H, Santos RL, Berger T, Mak TW, Tsolis RM, Bevins CL, Solnick JV, Dandekar S, Bäumler AJ
- Featured article, with preview by Eric Skaar: “A precious metal heist”, Cell Host Microbe. 2009 May 8;5(5):3. | Links: PubMed, DirectLink
- Research Highlights: “Taking iron from the fire”, Nature Reviews Microbiology, Vol 7, July 2009
Salmonella enterica Typhimurium SipA induces CXC-chemokine expression through p38MAPK and JUN pathways
Microbes Infect. 2009 Feb;11(2):302-10.
Figueiredo JF, Lawhon SD, Gokulan K, Khare S, Raffatellu M, Tsolis RM, Bäumler AJ, McCormick BA, Adams LG
Interleukin-23 orchestrates mucosal responses to Salmonella enterica serotype Typhimurium in the intestine
Infect Immun. 2009 Jan;77(1):387-98.
Godinez I, Raffatellu M, Chu H, Paixão TA, Haneda T, Santos RL, Bevins CL, Tsolis RM, Bäumler AJ
T cells help to amplify inflammatory responses induced by Salmonella enterica serotype Typhimurium in the intestinal mucosa
Infect Immun. 2008 May;76(5):2008-17.
Godinez I, Haneda T, Raffatellu M, George MD, Paixão TA, Rolán HG, Santos RL, Dandekar S, Tsolis RM, Bäumler AJ
Simian immunodeficiency virus-induced mucosal interleukin-17 deficiency promotes Salmonella dissemination from the gut
Nat Med. 2008 Apr;14(4):421-8.
Raffatellu M[1], Santos RL[1], Verhoeven DE, George MD, Wilson RP, Winter SE, Godinez I, Sankaran S, Paixao TA, Gordon MA, Kolls JK, Dandekar S, Bäumler AJ
[1]: Contributed equally
- Faculty of 1000 “Recommended Article”
The Vi-capsule prevents Toll-like receptor 4 recognition of Salmonella
Cell Microbiol. 2008 Apr;10(4):876-90.
Wilson RP, Raffatellu M, Chessa D, Winter SE, Tükel C, Bäumler AJ
The Salmonella enterica serotype Typhi regulator TviA reduces interleukin-8 production in intestinal epithelial cells by repressing flagellin secretion
Cell Microbiol. 2008 Jan;10(1):247-61.
Winter SE, Raffatellu M, Wilson RP, Rüssmann H, Bäumler AJ
The capsule encoding the viaB locus reduces interleukin-17 expression and mucosal innate responses in the bovine intestinal mucosa during infection with Salmonella enterica serotype Typhi
Infect Immun. 2007 Sep;75(9):4342-50.
Raffatellu M, Santos RL, Chessa D, Wilson RP, Winter SE, Rossetti CA, Lawhon SD, Chu H, Lau T, Bevins CL, Adams LG, Bäumler AJ
SIMPLE approach for isolating mutants expressing fimbriae
Appl Environ Microbiol. 2007 Jul;73(14):4455-62.
Nuccio SP, Chessa D, Weening EH, Raffatellu M, Clegg S, Bäumler AJ
Host restriction of Salmonella enterica serotype Typhi is not caused by functional alteration of SipA, SopB, or SopD
Infect Immun. 2005 Dec;73(12):7817-26.
Raffatellu M, Sun YH, Wilson RP, Tran QT, Chessa D, Andrews-Polymenis HL, Lawhon SD, Figueiredo JF, Tsolis RM, Adams LG, Bäumler AJ
CsgA is a pathogen-associated molecular pattern of Salmonella enterica serotype Typhimurium that is recognized by Toll-like receptor 2
Mol Microbiol. 2005 Oct;58(1):289-304.
Tükel C, Raffatellu M, Humphries AD, Wilson RP, Andrews-Polymenis HL, Gull T, Figueiredo JF, Wong MH, Michelsen KS, Akçelik M, Adams LG, Bäumler AJ
The Vi capsular antigen of Salmonella enterica serotype Typhi reduces Toll-like receptor-dependent interleukin-8 expression in the intestinal mucosa
Infect Immun. 2005 Jun;73(6):3367-74.
Raffatellu M, Chessa D, Wilson RP, Dusold R, Rubino S, Bäumler AJ
SipA, SopA, SopB, SopD, and SopE2 contribute to Salmonella enterica serotype typhimurium invasion of epithelial cells
Infect Immun. 2005 Jan;73(1):146-54.
Raffatellu M, Wilson RP, Chessa D, Andrews-Polymenis H, Tran QT, Lawhon S, Khare S, Adams LG, Bäumler AJ
The use of flow cytometry to detect expression of subunits encoded by 11 Salmonella enterica serotype Typhimurium fimbrial operons
Mol Microbiol. 2003 Jun;48(5):1357-76.
Humphries AD, Raffatellu M, Winter S, Weening EH, Kingsley RA, Droleskey R, Zhang S, Figueiredo J, Khare S, Nunes J, Adams LG, Tsolis RM, Bäumler AJ
IS200 fingerprinting of Salmonella enterica serotype Abortusovis strains isolated in Iran
Epidemiol Infect. 2002 Apr;128(2):333-6.
Nikbakht GH, Raffatellu M, Uzzau S, Tadjbakhsh H, Rubino S