Learning from bacterial competition in the host to develop antimicrobials

Nat Med. 2018 Aug;24(8):1097-1103.
Raffatellu M

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Siderophore-based immunization strategy to inhibit growth of enteric pathogens

Proc Natl Acad Sci U S A. 2016 Nov 22;113(47):13462-7.
Sassone-Corsi M, Chairatana P, Zheng T, Perez-Lopez A, Edwards RA, George MD, Nolan EM, Raffatellu M

  • Spotlight by Corrie Detweiler: “A New Way to Beat Intestinal Pathogens”, Trends Microbiol. 2017 Mar;25(3):169-170. | Links: PubMed, DirectLink
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Microcins mediate competition among Enterobacteriaceae in the inflamed gut

Nature. 2016 Dec 8;540(7632):280-283.
Sassone-Corsi M, Nuccio SP, Liu H, Hernandez D, Vu CT, Takahashi AA, Edwards RA, Raffatellu M

  • Research Highlight by Sarah Crunkhorn: “Microcins limit intestinal infection”, Nature Reviews Drug Discovery. 2017; 16:18. | Links: PubMed, DirectLink
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Salmonella Mitigates Oxidative Stress and Thrives in the Inflamed Gut by Evading Calprotectin-Mediated Manganese Sequestration

Cell Host Microbe. 2016 Jun 8;19(6):814-25.
Diaz-Ochoa VE, Lam D, Lee CS, Klaus S, Behnsen J, Liu JZ, Chim N, Nuccio SP, Rathi SG, Mastroianni JR, Edwards RA, Jacobo CM, Cerasi M, Battistoni A, Ouellette AJ, Goulding CW, Chazin WJ, Skaar EP, Raffatellu M

  • Cover article
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The Cytokine IL-22 Promotes Pathogen Colonization by Suppressing Related Commensal Bacteria

Immunity. 2014 Feb 20;40(2):262-73.
Behnsen J, Jellbauer S, Wong CP, Edwards RA, George MD, Ouyang W, Raffatellu M

  • Featured article, with preview by Denise Monack: “The Battle in the Gut”, Immunity. 2014 Feb 20;40(2):173-5. | Links: PubMed, DirectLink
  • Press Release
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Probiotic bacteria reduce Salmonella Typhimurium intestinal colonization by competing for iron

Cell Host Microbe. 2013 Jul 17;14(1):26-37.
Deriu E, Liu JZ, Pezeshki M, Edwards RA, Ochoa RJ, Contreras H, Libby SJ, Fang FC, Raffatellu M

  • Cover article, with preview by Guenter Weiss: “Intestinal Irony: How Probiotic Bacteria Outcompete Bad Bugs”, Cell Host Microbe. 2013 Jul 17;14(1):3. | Links: PubMed, DirectLink
  • Editor’s Choice: “Good and Bad Bacteria Fight for Iron in the Gut”, Science Translational Medicine, Vol 5, August 2013
  • Press Release
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Circadian clock regulates the host response to Salmonella

Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):9897-902.
Bellet MM[1], Deriu E[1], Liu JZ, Grimaldi B, Blaschitz C, Zeller M, Edwards RA, Sahar S, Dandekar S, Baldi P, George MD, Raffatellu M[2], Sassone-Corsi P[2]
[1,2]: Contributed equally

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Zinc sequestration by the neutrophil protein calprotectin enhances Salmonella growth in the inflamed gut

Cell Host Microbe. 2012 Mar 15;11(3):227-39.
Liu JZ, Jellbauer S, Poe AJ, Ton V, Pesciaroli M, Kehl-Fie TE, Restrepo NA, Hosking MP, Edwards RA, Battistoni A, Pasquali P, Lane TE, Chazin WJ, Vogl T, Roth J, Skaar EP, Raffatellu M

  • Featured article
  • Editor’s Choice: “In need of nutrients”, Science, Vol 335, March 2012
  • Research Highlights: ”A competitive edge for Salmonella”, Nature Reviews Microbiology, Vol 10, May 2012
  • Faculty of 1000 “Must Read”, 8
  • Press Release
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Lipocalin-2 resistance confers an advantage to Salmonella enterica serotype Typhimurium for growth and survival in the inflamed intestine

Cell Host Microbe. 2009 May 8;5(5):476-86.
Raffatellu M, George MD, Akiyama Y, Hornsby MJ, Nuccio SP, Paixao TA, Butler BP, Chu H, Santos RL, Berger T, Mak TW, Tsolis RM, Bevins CL, Solnick JV, Dandekar S, Bäumler AJ

  • Featured article, with preview by Eric Skaar: “A precious metal heist”, Cell Host Microbe. 2009 May 8;5(5):3. | Links: PubMed, DirectLink
  • Research Highlights: “Taking iron from the fire”, Nature Reviews Microbiology, Vol 7, July 2009
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Simian immunodeficiency virus-induced mucosal interleukin-17 deficiency promotes Salmonella dissemination from the gut

Nat Med. 2008 Apr;14(4):421-8.
Raffatellu M[1], Santos RL[1], Verhoeven DE, George MD, Wilson RP, Winter SE, Godinez I, Sankaran S, Paixao TA, Gordon MA, Kolls JK, Dandekar S, Bäumler AJ
[1]: Contributed equally

  • Faculty of 1000 “Recommended Article”
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